Publications

* co-first authors; ^# joint corresponding authors

2026

• S. P. Acebrón^#, J. Hattemer, T. Rausch, and A. De Jaime-Soguero^#, “Morphogen Gradients as Drivers of Mosaicism During Early Human Development.” BioEssays 48, no.3 (2026): e70128. doi: https://doi.org/10.1002/bies.70128

2025

• A. De Jaime-Soguero^#, M. Romitti, S. Costagliola, A. Jauch, G. Vilangappurath, K. Willert, F.Foijer, S.P. Acebron^#. Long-term prevention of aneuploidy in human pluripotent stem cells by fine-tuning GSK3 activity. bioRxiv (2025) doi: https://doi.org/10.1101/2025.10.27.684724

• Y. El Laithy, W.A. Abreu de Oliveira, A. Pabba, A. Qualizza, G. Cosemans, P. Garcia-Diaz, F. Richard, P. Athanasouli, C. Rios Luci, W. De Wispelaere, L. Mourao, S. Hamer, S. Moens, A. De Jaime-Soguero, M.F. Baietti, S.J. Hutten, J. Jonkers, S.-J. Sammut, S. Soenen, C.L.G.J. Scheele, A. Bruna, C. Desmedt, D. Annibali, F. Lluis. Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State. Cancer Research (2025). doi:  https://doi.org/10.1158/0008-5472.CAN-24-4165 

2024

• K.H. Ho, M. Trapp, C. Guida, R.L. Ivanova, A. De Jaime-Soguero, A. Jabali, C. Thomas, A. Salasova, O. Bernatik, C. Salio, S. Horschitz, M. Hasselblatt, M. Sassoe-Pognetto, L. Cajanek, H. Ishikawa, H. Schroten, C. Schwerk, S.P. Acebron, P. Angel, P. Koch, A. Patrizi. Activation of Wnt/Beta-Catenin signaling is critical for the tumorigenesis of choroid plexus. Neuro- Oncology, noae176 (2024). 1-17. doi: https://doi.org/10.1093/neuonc/noae176.

• A. De Jaime-Soguero*, J. Hattemer*, A. Bufe, A. Haas, J. van den Berg, V. van Batenburg, B. Das, B. di Marco, S. Androulaki, N. Bohly, J.J.M. Landry, B. Schoell, V.S. Rosa, L. Villacorta, Y. Baskan, M. Trapp, V. Benes, A. Chabes, M. Shahbazi, A. Jauch, U. Engel, A. Patrizi, R. Sotillo, A. van Oudenaarden, J. Bageritz, J. Alfonso, H. Bastians, and S.P. Acebron. Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress. Nature Communications (2024). 15, 7404 (2024). doi: https://doi.org/10.1038/s41467-024-51821-9

• J. Van den Berg, V. van Batenburg, C. Geisenberger, R. Tjeerdsma, A. de Jaime-Soguero, S.P. Acebron, M.A.T.M. Van Gut, A. van Oudenaarden. Quantifying DNA replication speeds in single cells by scEdU-seq. Nature Methods (2024) 21, 1175–1184. doi:  https://doi.org/10.1038/s41592-024-02308-4

2023

• A. Athanasouli*, M. Balli*, A. de Jaime-Soguero^#, A. Boel, S. Papanikolaou, B.K. van der Veer, A. Janiszewski, T. Vanhessche, A. Francis, Y.E. Laithy, A.L. Nigro, F. Aulicino, K.P. Koh, V. Pasque, M. Pia Cosma, C. Verfaillie, A. Zwijsen, B. Heindryckx, C. Nikolaou & F. Lluis^#.The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency. Nature Communications (2023) 14, 1210. doi: https://doi.org/10.1038/s41467-023-36914-1

2021

• A. Bufe, A. García-del Arco, M. Hennecke, A. de Jaime-Soguero,  M. Ostermaier, Y.C. Lin, A. Ciprianidis, J. Hattemer, U. Engel, P. Beli, H. Bastians, S.P. Acebron. Wnt signaling recruits KIF2A to the spindle to ensure chromosome alignment during mitosis. PNAS (2021) 118 (34), e2108145118. doi: https://doi.org/10.1073/pnas.2108145118

• N. Giebel*, A. de Jaime‐Soguero*, A. García-del Arco, J.J.M. Landry, M. Tietje, L. Villacorta, V. Benes, V. Fernandez-Saiz, S.P. Acebron. USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling. EMBO Reports (2021) 22 (5), e51415. doi: https://doi.org/10.15252/embr.202051415

• E. Nistal-Villan, J. Argemi, A. de Jaime‐Soguero, R. Ferrero, M. di Scala, E. Rodriguez-Garcia, A. Coll, S. Rius-Rocabert, J. Prieto, G. Gonzalez-Aseguinolaza, T. Aragon. Linking the Expression of Therapeutic Genes to Unfolded Protein Response: A New Option for Anti-Hepatitis B Virus Gene Therapy. Human Gene Therapy (2021), Apr;32(7-8):341-348. doi: https://doi.org/10.1089/hum.2019.336

2018

• A. de Jaime‐Soguero*, W.A.A. de Oliveira*, F. Lluis. The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency. Genes (2018), 9 (2), 93. doi: https://doi.org/10.3390/genes9020093 

2017

• A. De Jaime-Soguero*, F. Aulicino*, G. Ertaylan, A. Griego, A. Cerrato, A. Tallam, A. Del Sol, M. Pia Cosma, F. Lluis. Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus. PLoS Genetics (2017), 13 (3), e1006682. doi: https://doi.org/10.1371/journal.pgen.1006682

• A.L. Nigro*, A. de Jaime-Soguero*, R. Khoueiry, D.S. Cho, G.M. Ferlazzo, I. Perini, V.A. Escalona, X. Lopez-Aranguren, S.M. C. de Sousa Lopes, K.P. Koh, P.G. Conaldi, W.S. Hu, A. Zwijsen, F. Lluis, C. Verfaillie. PDGFRα⁺ cells in embryonic stem cell culture represent the in vitro equivalent of the pre-implantation primitive endoderm precursors. Stem Cell Reports (2017) 8(2): 318–333. doi: https://doi.org/10.1016/j.stemcr.2016.12.010